CH 390L: Mass Spectrometry

Spring 2006, MW 8:30 - 9:45 am, WEL 4.308

Class Material

(class documents and announcements will be posted below)

Feb 28th: Literature articles by topic (some articles are linked to PDF files):

ESI: Kebarle, P. and Tang, L. "From Ions in Solution to Ions in the Gas Phase," Anal. Chem. 1993, 65, 972A.

MALDI: Beavis, R.C. "Matrix-Assisted UV LD: Evolution and Principles," Org. Mass Spectrom. 1992, 27, 653.

Hillenkamp, F.; Karas, M.; Beavis, R.C.; Chait, B.T. "MALDI Mass Spectrometry of Biopolymers," Anal. Chem. 1991, 63, 1193A.

DESI: Takats, Z.; Wiseman, J.M.; Cooks, J. Mass Spectrom. 2005, 40, 1261-1275.

DART: Cody, R.B.; Laramee, J.A.; Dupont, H.D. Anal. Chem. 2005, 77, 2297-2302.

TOF: Cotter, R.J. "TOF MS: An Increasing Role in the Life Sciences," Biomed. Environ. Mass Spectrom., 1989, 18, 513-532.

Cotter, R.J. Anal. Chem. 1999, 445A-451A.

FTICR: Comisarow, M.B. and Marshall, A.G. J. Mass Spectrom. 1996, 31, 581-585.

Marshall, A.G. Acc. Chem. Res. 1985, 18, 316-322.

Quadrupole Ion Traps: March, R.E. "Ion Trap Mass Spectrometry," Int. J. Mass Spec. Ion Proc. 1992, 118/119, 71-135.

Todd, J.F.J. "Ion Trap Mass Spectrometers: Past, Present and Future," Mass Spec. Rev. 1991, 10, 3-52.

Q-TOF: Chernushevich, I.; Loboda, A.; Thomson, B. J. Mass Spectrom. 2001, 36, 849-865.

General: McLucky, S.A. and Wells, J.M. Chem. Rev. 2001, 101, 571-606.

Detectors: Koppenall, D.W.; Denton, M.B.; Hieftje, G.M.; Barnes, J.H. Anal. Chem. 2005, 77, 419A-427A.

Jan 30th: The review article about MALDI can be found here.

Jan 19th: Check out the articles about resolution and mass accuracy.

Jan 18th: First homework assignment due on 1/30/06.

Contact Info.

Dr. Jennifer Brodbelt

Office Hour: Monday, 10:00 am

Rm 3.424

TA: Carolyn Mazzitelli

Office Hour: Tuesday, 11:00 am

Rm. 3.424N

Links of Interest

Journal of the American Society for Mass Spectrometry: The title says it all.

ChemCalc: Calculates molecular formula, molecular mass, exact mass, elemental analysis and plots the isotopic distribution graph.

Protein Prospector: For all things proteomics.

Kermit Murray's Mass Spec Blog: A blog! About mass spec!

 

 

 

 

 

 

 

 

last upated on 3/2/06